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Investigating how microcircuit abnormalities modulate brain-wide network dynamics to cause seizures across variant SCN1A mutations, using a zebrafish [Clear]

# Title Funder Funding Start End Status
1 Human organoid modelling of neurogenetic epilepsy syndromes MRC
£0
 Sept. 30, 2021 Sept. 29, 2024 Active
2 Subunit specific mechanisms by which potassium channels mediate intrinsic plasticity and neuronal integration in the auditory pathway BBSRC
£1,441,012
 Feb. 1, 2018 Jan. 31, 2022 Closed
3 Effects of neurotransmitters on axonal KV7 channel function in hippocampal neurons BBSRC
£724,242
 April 29, 2014 July 30, 2018 Closed
4 Fragile X mental retardation protein interaction with neuronal voltage-gated calcium channels: mechanism and consequences MRC
£1,661,120
 Dec. 1, 2012 Nov. 30, 2015 Closed
5 Intrinsic plasticity of neuronal excitability in the auditory brainstem and neocortex: nitrergic signalling to voltage-gated potassium channels MRC
£1,384,778
 Feb. 4, 2013 July 30, 2016 Closed
6 Integration of calcium signalling mechanisms in neural modelling BBSRC
£514,446
 March 1, 2011 Feb. 28, 2014 Closed
7 Single neuron computation MRC
£3,429,092
 Nov. 1, 2002 Dec. 31, 2009 Closed
8 A Functional Analysis of Resistance to Pyrethroid Insecticides in the malaria vector Anopheles gambiae MRC
£841,094
 March 1, 2022 Feb. 28, 2025 Active
9 Dissection of voltage-gated ion channel physiology in vivo in the C. elegans oxygen-sensing neural circuit MRC
£1,235,606
 Feb. 15, 2016 April 29, 2020 Closed
10 Role of A- and M-type K+ and Ih currents and channels in spontaneous pain MRC
£748,288
 Dec. 1, 2007 May 30, 2011 Closed
11 Causal relation between dendritic morphology, voltage gated channel expression and presynaptic release mechanisms ? MRC
£688,214
 May 31, 2005 Nov. 30, 2008 Closed
12 MICA: Neuronal Arginine Metabolism in Health and Disease MRC
£2,684,370
 March 31, 2020 March 31, 2024 Active
13 MICA: Neuronal Arginine Metabolism in Health and Disease MRC
£6,710,925
 March 31, 2020 March 31, 2025 Active
14 Molecular mechanisms of voltage-gated potassium channel clustering in myelinated axons BBSRC
£1,173,476
 March 31, 2020 March 30, 2023 Active
15 HCN ion channels and pain BBSRC
£833,542
 June 30, 2012 Nov. 30, 2013 Closed
16 HCN ion channels and pain BBSRC
£428,670
 Dec. 1, 2013 June 29, 2015 Closed
17 Understanding mechanisms of cortical spreading depression in epilepsy and migraine EPSRC
£0
 Sept. 22, 2019 Sept. 29, 2023 Active
18 Proteolytic processing of sodium channel beta1 subunits BBSRC
£0
 Sept. 30, 2015 Sept. 29, 2019 Closed
19 Novel gene therapy strategy for refractory epilepsy MRC
£0
 Sept. 24, 2017 Sept. 29, 2021 Closed
20 MICA: A comprehensive genomic and functional approach to discover new ion channel targets for human pain treatment MRC
£1,997,354
 Sept. 30, 2012 June 29, 2016 Closed
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