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Structure and Function of Voltage-Gated Ion Channels and their Applications for Rational Drug Design [Clear]

# Title Funder Funding Start End Status
1 Crystal structure analysis of a voltage-gated sodium channel BBSRC
£1,026,592
 April 30, 2010 June 29, 2014 Closed
2 Parallel electrophysiological characterization of sodium channels EPSRC
£1,067,438
 Sept. 30, 2010 Sept. 29, 2014 Closed
3 Parallel electrophysiological characterization of sodium channels EPSRC
£956,988
 May 31, 2010 May 30, 2014 Closed
4 Chimeric Human-NavMs Sodium Channel Constructs for Structure/Function Studies of Selective Toxin Binding BBSRC
£0
 Sept. 22, 2019 Sept. 29, 2023 Active
5 Structure and Function of the Human 1.8 Voltage-Gated Sodium Channel Associated with Pain Sensation BBSRC
£1,161,336
 Sept. 30, 2017 Sept. 29, 2021 Closed
6 Exploitation of a Pharmacological 'Master Switch' to Probe the K+ Channel Selectivity Filter Gating Mechanism BBSRC
£817,418
 March 1, 2019 June 29, 2022 Closed
7 Probing the dynamics of agonist drug interaction with Cys-loop channels by single-molecule recording MRC
£1,076,130
 Nov. 1, 2012 April 29, 2016 Closed
8 Role of A- and M-type K+ and Ih currents and channels in spontaneous pain MRC
£748,288
 Dec. 1, 2007 May 30, 2011 Closed
9 A Functional Analysis of Resistance to Pyrethroid Insecticides in the malaria vector Anopheles gambiae MRC
£841,094
 March 1, 2022 Feb. 28, 2025 Active
10 The lighter touch: minimally-invasive optical modulation of Ca2+-activated K+ ion channels EPSRC
£1,082,056
 June 30, 2007 Sept. 29, 2010 Closed
11 Multi-protein assembly of intracellular ion-sensitive potassium channel complexes BBSRC
£465,868
 April 30, 2006 April 29, 2009 Closed
12 The molecular basis of target site and metabolic insecticide resistance BBSRC
£1,146,221
 March 31, 2008 March 30, 2012 Closed
13 Effects of neurotransmitters on axonal KV7 channel function in hippocampal neurons BBSRC
£724,242
 April 29, 2014 July 30, 2018 Closed
14 Molecular mechanisms of voltage-gated potassium channel clustering in myelinated axons BBSRC
£1,173,476
 March 31, 2020 March 30, 2023 Active
15 Modulation of thermo-TRP ion channel activity by phosphorylation and trafficking to the membrane BBSRC
£779,192
 Jan. 1, 2008 Dec. 31, 2010 Closed
16 Modulation of thermo-TRP ion channel activity by phosphorylation and trafficking to the membrane BBSRC
£1,947,980
 Jan. 1, 2008 Dec. 31, 2010 Closed
17 Cellular Dynamics of Voltage-Gated Calcium Channels: Control Via Gabapentinoid-sensitive Auxiliary Alpha2-Delta Subunits MRC
£1,167,304
 Jan. 14, 2008 April 12, 2011 Closed
18 Identifying the mechanism underlying the effect of neurotoxic spider venoms on the parasite Fasciola hepatica. BBSRC
£0
 Sept. 30, 2020 March 30, 2025 Active
19 Glycosylphosphatidylinositol (GPI)-anchoring of calcium channel alpha2delta subunits: function and pharmacology MRC
£1,929,610
 April 30, 2011 Oct. 30, 2015 Closed
20 Microsystems for coupled expression and electrophysiology of ion channels EPSRC
£203,872
 June 22, 2011 Nov. 29, 2013 Closed
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