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Chimeric Human-NavMs Sodium Channel Constructs for Structure/Function Studies of Selective Toxin Binding [Clear]

# Title Funder Funding Start End Status
1 Parallel electrophysiological characterization of sodium channels EPSRC
£1,067,438
 Sept. 30, 2010 Sept. 29, 2014 Closed
2 Parallel electrophysiological characterization of sodium channels EPSRC
£956,988
 May 31, 2010 May 30, 2014 Closed
3 Crystal structure analysis of a voltage-gated sodium channel BBSRC
£1,026,592
 April 30, 2010 June 29, 2014 Closed
4 Probing the dynamics of agonist drug interaction with Cys-loop channels by single-molecule recording MRC
£1,076,130
 Nov. 1, 2012 April 29, 2016 Closed
5 Structure and Function of the Human 1.8 Voltage-Gated Sodium Channel Associated with Pain Sensation BBSRC
£1,161,336
 Sept. 30, 2017 Sept. 29, 2021 Closed
6 The role of alpha3-GABAA receptors in mono-aminergic neuronal function BBSRC
£0
 Sept. 30, 2015 Sept. 29, 2019 Closed
7 Molecular mechanisms of voltage-gated potassium channel clustering in myelinated axons BBSRC
£1,173,476
 March 31, 2020 March 30, 2023 Active
8 Multi-protein assembly of intracellular ion-sensitive potassium channel complexes BBSRC
£465,868
 April 30, 2006 April 29, 2009 Closed
9 Microsystems for coupled expression and electrophysiology of ion channels EPSRC
£203,872
 June 22, 2011 Nov. 29, 2013 Closed
10 Peripheral voltage gated sodium channels in health and disease MRC
£2,729,948
 May 31, 2010 April 29, 2016 Closed
11 Exploitation of a Pharmacological 'Master Switch' to Probe the K+ Channel Selectivity Filter Gating Mechanism BBSRC
£817,418
 March 1, 2019 June 29, 2022 Closed
12 Protein engineering to enhance the commercial potential of novel fusion protein based biopesticides. BBSRC
£0
 Sept. 30, 2019 Sept. 29, 2023 Active
13 Molecular Mechanisms for a Novel Class of Openers Targeting Voltage- and Calcium-activated Potassium Channels. MRC
£0
 Sept. 30, 2016 March 29, 2021 Closed
14 Glycosylphosphatidylinositol (GPI)-anchoring of calcium channel alpha2delta subunits: function and pharmacology MRC
£1,929,610
 April 30, 2011 Oct. 30, 2015 Closed
15 Identifying the mechanism underlying the effect of neurotoxic spider venoms on the parasite Fasciola hepatica. BBSRC
£0
 Sept. 30, 2020 March 30, 2025 Active
16 Role of voltage-dependent calcium channels in nociceptive transmission under normal and neuropathic conditions BBSRC
£465,984
 Jan. 1, 2007 Dec. 31, 2009 Closed
17 Role of HCN ion channels in pain BBSRC
£145,080
 Sept. 30, 2008 Sept. 29, 2012 Closed
18 Design and construction of electrogenic cell-based biosensors for pathogens and toxins BBSRC
£956,060
 Nov. 30, 2013 Nov. 29, 2017 Closed
19 Approaching Carbon-zero cardiac safety testing in drug development: Green Biology Innovate UK
£119,908
 Sept. 30, 2020 Dec. 31, 2020 Closed
20 Structure and Function of Voltage-Gated Ion Channels and their Applications for Rational Drug Design BBSRC
£1,064,830
 March 30, 2014 Sept. 29, 2018 Closed
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