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Human organoid modelling of neurogenetic epilepsy syndromes [Clear]

# Title Funder Funding Start End Status
1 Investigating how microcircuit abnormalities modulate brain-wide network dynamics to cause seizures across variant SCN1A mutations, using a zebrafish MRC
£0
 Sept. 30, 2017 Dec. 31, 2021 Closed
2 Subunit specific mechanisms by which potassium channels mediate intrinsic plasticity and neuronal integration in the auditory pathway BBSRC
£1,441,012
 Feb. 1, 2018 Jan. 31, 2022 Closed
3 Effects of neurotransmitters on axonal KV7 channel function in hippocampal neurons BBSRC
£724,242
 April 29, 2014 July 30, 2018 Closed
4 Understanding mechanisms of cortical spreading depression in epilepsy and migraine EPSRC
£0
 Sept. 22, 2019 Sept. 29, 2023 Active
5 Mitochondrial function and transition from glycolysis to oxidative phosphorylation in differentiating induced pluripotent stem cells BBSRC
£1,629,425
 Feb. 24, 2012 Feb. 23, 2015 Closed
6 Intrinsic plasticity of neuronal excitability in the auditory brainstem and neocortex: nitrergic signalling to voltage-gated potassium channels MRC
£1,384,778
 Feb. 4, 2013 July 30, 2016 Closed
7 Novel gene therapy strategy for refractory epilepsy MRC
£0
 Sept. 24, 2017 Sept. 29, 2021 Closed
8 Dissection of voltage-gated ion channel physiology in vivo in the C. elegans oxygen-sensing neural circuit MRC
£1,235,606
 Feb. 15, 2016 April 29, 2020 Closed
9 Role of LGI and ADAM proteins in the functional organization of the myelinated axon BBSRC
£0
 Sept. 30, 2017 Sept. 29, 2021 Closed
10 An in vitro human cell assay to investigate the effects of psychiatric risk gene CACNA1C dosage on neuronal network activity MRC
£0
 Sept. 30, 2017 July 25, 2021 Closed
11 Exploring subcellular mitochondrial heterogeneity in neurons: a multimodal approach BBSRC
£0
 Sept. 30, 2022 Sept. 30, 2026 Active
12 Training in hIPSC differentiation protocols to generate motor neuron-muscle cultures to replace rat models in study of mitochondria on axon physiology NC3Rs
£265,140
 Feb. 1, 2017 Jan. 31, 2019 Closed
13 Role of A- and M-type K+ and Ih currents and channels in spontaneous pain MRC
£748,288
 Dec. 1, 2007 May 30, 2011 Closed
14 MICA: A comprehensive genomic and functional approach to discover new ion channel targets for human pain treatment MRC
£1,997,354
 Sept. 30, 2012 June 29, 2016 Closed
15 The genetic architecture and functional role of the mitochondrial transcriptome in the Human Brain BBSRC
£0
 Sept. 26, 2021 Sept. 29, 2025 Active
16 The genetic architecture and functional role of the mitochondrial transcriptome in the Human Brain BBSRC
£0
 Sept. 30, 2021 Sept. 30, 2025 Active
17 Investigating the role of Kv3.4 potassium channels in neurodegenerative pathways of relevance to Alzheimer's Disease. MRC
£0
 Sept. 30, 2018 March 30, 2022 Active
18 Molecular mechanisms of voltage-gated potassium channel clustering in myelinated axons BBSRC
£1,173,476
 March 31, 2020 March 30, 2023 Active
19 MICA: Neuronal Arginine Metabolism in Health and Disease MRC
£2,684,370
 March 31, 2020 March 31, 2024 Active
20 MICA: Neuronal Arginine Metabolism in Health and Disease MRC
£6,710,925
 March 31, 2020 March 31, 2025 Active
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