A sustainable route to high value terpenoid production in cyanobacteria

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Title
A sustainable route to high value terpenoid production in cyanobacteria

CoPED ID
19a6a008-11ef-4299-859e-d62a35e4cc70

Status
Active

Funder

Value
No funds listed.

Start Date
Sept. 30, 2018

End Date
Dec. 30, 2022

Description

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Cyanobacteria are photosynthetic prokaryotes capable of fixing CO2 as a sole carbon source and utilising light as an energy source. They have attracted significant interest as biofuel and high-value pharmaceutical/nutraceutical producing organisms, with several laboratories seeking to re-engineer cyanobacteria as cell factory platforms. Terpenoids are extremely diverse natural products with more than 55,000 identified. Terpenoids are primarily produced by plants and play important roles in both primary and secondary metabolism, they also have a variety of commercial applications. Therefore the sustainable production of terpenoids in cyanobacteria utilising sunlight and CO2 is a very attractive proposition. Terpene synthases and precursor pathways have already been implemented in cyanobacteria to increase the production of various different terpenes, however to be commercially viable productivity needs to be significantly increased. This project aims to engineer a cyanobacterial strain with improved flux down the MEP pathway, utilising a combination of dynamic regulation, metabolomic flux analysis and fermentation. Thus directing more photosynthetic carbon towards terpenoid production.

Samantha Bryan SUPER_PER
Philip Ssentongo STUDENT_PER

Subjects by relevance
  1. Cyanobacteria
  2. Photosynthesis
  3. Bioenergy
  4. Natural diversity
  5. Metabolism
  6. Biomass (industry)
  7. Bacteria
  8. Carbon dioxide

Extracted key phrases
  1. High value terpenoid production
  2. Sustainable production
  3. Engineer cyanobacteria
  4. Sustainable route
  5. Sole carbon source
  6. Photosynthetic prokaryote capable
  7. Photosynthetic carbon
  8. Value pharmaceutical
  9. Energy source
  10. Metabolomic flux analysis
  11. Cell factory platform
  12. MEP pathway
  13. Precursor pathway
  14. Improved flux
  15. Diverse natural product

Related Pages

UKRI project entry

UK Project Locations