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[{"model": "core.projectfund", "pk": 30840, "fields": {"project": 8066, "organisation": 7, "amount": 0, "start_date": "2021-09-26", "end_date": "2025-09-29", "raw_data": 48803}}]
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| Jan. 28, 2023, 11:09 a.m. |
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[{"model": "core.projectorganisation", "pk": 87907, "fields": {"project": 8066, "organisation": 1998, "role": "LEAD_ORG"}}]
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| Jan. 28, 2023, 11:09 a.m. |
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[{"model": "core.projectperson", "pk": 54930, "fields": {"project": 8066, "person": 11186, "role": "STUDENT_PER"}}]
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| Jan. 28, 2023, 11:09 a.m. |
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[{"model": "core.projectperson", "pk": 54929, "fields": {"project": 8066, "person": 6873, "role": "SUPER_PER"}}]
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{"title": ["", "The genetic architecture and functional role of the mitochondrial transcriptome in the Human Brain"], "description": ["", "\nMitochondria are key to many fundamental cellular processes, including cellular energy\nproduction and cell death. Mitochondria perform different tasks in varied cell types, but it is\ngenerally understood that the role of mitochondria becomes even more important in tissues\nwith higher energy demand such as the brain and heart. In the brain, mitochondria are\nrequired to dynamically change their form and function in response to fluctuating demands,\nand they are key players in the modulation of synaptic signalling and neurite regeneration.\nTheir importance in the brain is underscored by the accumulating evidence that the\ndysfunction of mitochondrial processes is key to many neurological disorders. As such, it is\nvital to understand how mitochondrial processes are regulated in the brain and whether this\nvaries across different cell types.\nThe first objective of this project is to integrate complex genetic, transcriptomic and singlecell\ndata to identify brain and cell-type specific regulation of key mitochondrial processes that\ninfluence downstream function (such as transcription, RNA modification and localisation)\nacross a large number of human individuals. This will involve using computational methods to\nconsider how relationships between the nuclear and mitochondrial genomes vary across the\nbrain. The second objective of the project will be to identify the downstream consequences of\nmodulating these processes on mitochondrial function, through the genetic manipulation of\niPSC-derived neuronal and astrocyte cell models. Finally, these results will then be considered\nfor their importance in ageing processes and a range of neurological disorders.\nThe project will be strengthened by the complementary skills sets of the two supervisors,\nwho will provide support in each area: Dr Hodgkinson is an expert in the computational\nanalysis of mitochondrial processes, whereas Dr Devine is an expert in using iPSCs as\nfunctional model systems and understanding the roles of mitochondria in neurons and\nneurodegenerative diseases.\n\n"], "extra_text": ["", "\n\n\n\n"], "status": ["", "Active"]}
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| Jan. 28, 2023, 10:52 a.m. |
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{"external_links": [33146]}
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| Jan. 28, 2023, 10:52 a.m. |
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[{"model": "core.project", "pk": 8066, "fields": {"owner": null, "is_locked": false, "coped_id": "28e01ca9-eb09-4e88-89c1-db569424e4e9", "title": "", "description": "", "extra_text": "", "status": "", "start": null, "end": null, "raw_data": 48799, "created": "2023-01-28T10:38:33.426Z", "modified": "2023-01-28T10:38:33.426Z", "external_links": []}}]
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