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[{"model": "core.projectfund", "pk": 29175, "fields": {"project": 6393, "organisation": 7, "amount": 400751, "start_date": "2015-09-30", "end_date": "2018-09-29", "raw_data": 47783}}]
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{"external_links": []}
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[{"model": "core.projectfund", "pk": 21308, "fields": {"project": 6393, "organisation": 7, "amount": 400751, "start_date": "2015-09-30", "end_date": "2018-09-29", "raw_data": 29761}}]
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| April 11, 2022, 3:48 a.m. |
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[{"model": "core.projectorganisation", "pk": 80587, "fields": {"project": 6393, "organisation": 8115, "role": "COLLAB_ORG"}}]
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| April 11, 2022, 3:48 a.m. |
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[{"model": "core.projectorganisation", "pk": 80586, "fields": {"project": 6393, "organisation": 1569, "role": "COLLAB_ORG"}}]
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| April 11, 2022, 3:48 a.m. |
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[{"model": "core.projectorganisation", "pk": 80585, "fields": {"project": 6393, "organisation": 22, "role": "COLLAB_ORG"}}]
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| April 11, 2022, 3:48 a.m. |
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[{"model": "core.projectorganisation", "pk": 80584, "fields": {"project": 6393, "organisation": 2207, "role": "COLLAB_ORG"}}]
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| April 11, 2022, 3:48 a.m. |
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[{"model": "core.projectorganisation", "pk": 80583, "fields": {"project": 6393, "organisation": 5490, "role": "LEAD_ORG"}}]
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| April 11, 2022, 3:48 a.m. |
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[{"model": "core.projectperson", "pk": 49744, "fields": {"project": 6393, "person": 9036, "role": "PI_PER"}}]
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| April 11, 2022, 1:48 a.m. |
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{"title": ["", "14 ERA-CAPS. Designing starch - harnessing carbohydrate polymer synthesis in plants"], "description": ["", "\nStarch is a natural product produced by most land plants and algae with remarkable physicochemical\nproperties. It is composed of two polymers of glucose: amylose, a predominantly linear polymer, and amylopectin, which also contains branch points, resulting in a tree-like structure. The simple constituents of starch is contrasted by its complex and highly ordered structure, in which crystalline and amorphous layers alternate in a defined and regular fashion. This structure gives starch unique\nphysicochemical properties, which make it an exceptionally tightly packed energy storage that is of\nsuch tremendous importance for the human diet and economy as a whole. Despite decades of intense\nresearch, it is still not understood how precisely starch granule biogenesis initiates and progresses. A\nrelatively small number of enzymes are involved, but it is unclear how their activities are coordinated\nin order to ultimately control the structure and properties of starch.\nThe objective of our project is to gain a profound understanding of the regulation and control of the\nbiophysical and biochemical processes involved in the formation of the complex polymeric structure\nthat is the starch granule. We will apply this understanding to recreate the synthesis of starch in the test tube\nand learn to control its physical and chemical properties in a targeted way. By producing starch\nsynthesising enzymes in yeast, an organism not natively producing starch, we will design starches with\nnew properties.\n\n"], "extra_text": ["", "\nTechnical Abstract:\nStarch is a natural product produced by most land plants and algae with remarkable physicochemical\nproperties. Starch is composed of two polymers of glucose: amylose, a predominantly linear polymer\nof alpha-1,4 linked glucose units, and amylopectin, which also contains alpha-1,6 linkages (branch points)\nresulting in a tree-like structure. The simple constituents of starch (one type of monomer and two\ntypes of linkages) is contrasted by its complex and highly ordered structure, in which crystalline and\namorphous layers alternate in a defined and regular fashion. This structure gives starch unique\nphysicochemical properties, which make it an exceptionally tightly packed energy storage that is of\nsuch tremendous importance for the human diet and economy as a whole. Despite decades of intense\nresearch, it is still not understood how precisely starch granule biogenesis initiates and progresses. A\nrelatively small number of enzymes are involved, but it is unclear how their activities are coordinated\nin order to ultimately control the structure and properties of starch.\nThe objective of our project is to gain a profound understanding of the regulation and control of the\nbiophysical and biochemical processes involved in the formation of the complex polymeric structure\nthat is the starch granule. We will apply this understanding to recreate the synthesis of starch in vitro\nand learn to control its physical and chemical properties in a targeted way. By expressing starch\nsynthesising enzymes in yeast, an organism not natively producing starch, we will design starches with\ndesired properties in vivo. This will be translated back in planta to genetically engineer plants\nproducing starch with desired, pre-defined physicochemical properties.\n\nPotential Impact:\nWho will benefit from this research?\n\nThe goal of this research is to provide a fundamental underpinning that will enable the generation of new starches with defined properties through genetic engineering - i.e. synthetic biology. As such, the project will benefit:\n\n. scientists with an interest in starch structure, properties and applications\n. scientists with an interest in metabolic engineering\n. the food processing, pharmaceutical tableting and paper processing industries, which makes of starches with different properties\n. the bioenergy industry, with interests in the generation and controlled degradation of sugar-based feedstocks\n\nHow will they benefit from this research?\n\nThe ability to genetically 'dial-up' starch properties will enable:\n\n. better controlled drug release from tablets, supporting improved medication\n. improved food functionality, potentially with lower calorific impact on and hence health benefits for the consumer\n\nThese impacts ought to be achievable within 5-10 years of the finalisation of standard operating procedures arising from this program.\n\nSynthetic biology approaches to be develop din this program will provide a basis set of components for wider glycoengineering, with potential impact on the production and efficacy of biopharmaceuticals. \n\nThe program also challenges convention and will provide an opportunity for the postdocs in the program to span physical and life sciences, theory and experiment, acquiring contemporary skills for the biotech job market.\n\n\n"], "status": ["", "Closed"]}
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| April 11, 2022, 1:48 a.m. |
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{"external_links": [23530]}
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| April 11, 2022, 1:48 a.m. |
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[{"model": "core.project", "pk": 6393, "fields": {"owner": null, "is_locked": false, "coped_id": "7096bce0-d543-4fff-8216-fb95edec756a", "title": "", "description": "", "extra_text": "", "status": "", "start": null, "end": null, "raw_data": 29745, "created": "2022-04-11T01:43:07.584Z", "modified": "2022-04-11T01:43:07.584Z", "external_links": []}}]
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