History of changes to: MP1: a novel enzyme for bio-manufacturing Adipic Acid
Date Action Change(s) User
Nov. 27, 2023, 2:13 p.m. Added 35 {"external_links": []}
Nov. 20, 2023, 2:03 p.m. Added 35 {"external_links": []}
Nov. 13, 2023, 1:33 p.m. Added 35 {"external_links": []}
Nov. 6, 2023, 1:31 p.m. Added 35 {"external_links": []}
Aug. 14, 2023, 1:31 p.m. Added 35 {"external_links": []}
Aug. 7, 2023, 1:32 p.m. Added 35 {"external_links": []}
July 31, 2023, 1:34 p.m. Added 35 {"external_links": []}
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July 10, 2023, 1:26 p.m. Added 35 {"external_links": []}
July 3, 2023, 1:26 p.m. Added 35 {"external_links": []}
June 26, 2023, 1:26 p.m. Added 35 {"external_links": []}
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April 10, 2023, 1:25 p.m. Added 35 {"external_links": []}
April 3, 2023, 1:26 p.m. Added 35 {"external_links": []}
Jan. 28, 2023, 11:08 a.m. Created 43 [{"model": "core.projectfund", "pk": 28206, "fields": {"project": 5409, "organisation": 4, "amount": 349946, "start_date": "2022-02-01", "end_date": "2023-07-30", "raw_data": 44953}}]
Jan. 28, 2023, 11:08 a.m. Created 40 [{"model": "core.projectperson", "pk": 54303, "fields": {"project": 5409, "person": 12403, "role": "PM_PER"}}]
Jan. 28, 2023, 10:52 a.m. Added 35 {"external_links": []}
April 11, 2022, 3:47 a.m. Created 43 [{"model": "core.projectfund", "pk": 20324, "fields": {"project": 5409, "organisation": 4, "amount": 349946, "start_date": "2022-02-01", "end_date": "2023-07-30", "raw_data": 26946}}]
April 11, 2022, 3:47 a.m. Created 41 [{"model": "core.projectorganisation", "pk": 77096, "fields": {"project": 5409, "organisation": 7494, "role": "PARTICIPANT_ORG"}}]
April 11, 2022, 3:47 a.m. Created 41 [{"model": "core.projectorganisation", "pk": 77095, "fields": {"project": 5409, "organisation": 7494, "role": "LEAD_ORG"}}]
April 11, 2022, 3:47 a.m. Created 40 [{"model": "core.projectperson", "pk": 47529, "fields": {"project": 5409, "person": 8173, "role": "PM_PER"}}]
April 11, 2022, 1:48 a.m. Updated 35 {"title": ["", "MP1: a novel enzyme for bio-manufacturing Adipic Acid"], "description": ["", "\n**PROBLEM:** Adipic acid (ADP; aka hexanedioic acid) is an important chemical. It is used for manufacturing many common materials including polyurethanes, plasticisers used in PVC production, and Nylon 6,6 (which consumes ~75% of all ADP made).\n\nADP is manufactured via a multi-step reaction:\n\n* Benzene is reduced to cyclohexane at high-pressures and high temperatures using a catalyst (e.g., Ni/Al2O3) and a hydrogen feed.\n* Cyclohexane is oxidized using air plus a metal catalyst (e.g., cobalt) to generate a cyclohexanone and cyclohexanol mixture (KA oil).\n* KA oil is oxidized with nitric oxide and copper/ammonium metavanadate to produce ADP \\[conversion yield ~95%\\].\n\nIndustrial ADP manufacturing causes significant environmental problems:\n\n* Around 10% of global nitric oxide (NOx) emissions are from ADP production.\n* The benzene feedstock is a non-renewable petroleum compound and volatile carcinogen.\n* Spent metal catalysts create toxic waste streams.\n\n**OPPORTUNITY:** Mellizyme are engineering a novel enzyme 'MP1' and have recently identified that it exhibits activity that enables the conversion of cyclohexane to ADP in air, enabling a greener ADP manufacturing method.\n\n**KEY PROJECT OBJECTIVES:** Deploy synthetic biology approaches to engineer MP1 to increase its thermostability, conversion rate speed, and diminish the formation of unwanted by-products. The project outputs will help Mellizyme to plan a future collaborative industrial demonstrator project showing how MP1 can be used at-scale for industrial ADP manufacturing.\n\n**STATE-OF-THE-ART LIMITATIONS**\n\n* Chemosynthetic methods of ADP manufacture suffer low conversion rates of cyclohexane and selectivity issues, leading to the formation of diacid contaminants, posing purification problems.\n* Catalytic degradation of NOx requires additional capital and energy expenditures.\n* Biomass-derived routes frequently require expensive precious metal catalysts.\n\n**MP1 INNOVATIONS/USPs**\n\n* MP1 works at atmospheric pressure and at a lower temperature than existing methods. This significantly reduces the energy requirement for ADP manufacturing using MP1 when compared to the high-pressures and high temperatures needed for the usual routes by which ADP is manufactured.\n* MP1 removes the need for metal catalysts, preserving rare metals, and stopping toxic metal waste formation.\n* Zero NOx production, supporting net zero targets.\n\n"], "extra_text": ["", "\n\n\n\n"], "status": ["", "Active"]}
April 11, 2022, 1:48 a.m. Added 35 {"external_links": [20195]}
April 11, 2022, 1:48 a.m. Created 35 [{"model": "core.project", "pk": 5409, "fields": {"owner": null, "is_locked": false, "coped_id": "edfb986e-a2a6-421a-9c5c-21c943bf0245", "title": "", "description": "", "extra_text": "", "status": "", "start": null, "end": null, "raw_data": 26932, "created": "2022-04-11T01:40:50.196Z", "modified": "2022-04-11T01:40:50.196Z", "external_links": []}}]