History of changes to: Investigating how microcircuit abnormalities modulate brain-wide network dynamics to cause seizures across variant SCN1A mutations, using a zebrafish
Date Action Change(s) User
Nov. 27, 2023, 2:12 p.m. Added 35 {"external_links": []}
Nov. 20, 2023, 2:03 p.m. Added 35 {"external_links": []}
Nov. 13, 2023, 1:33 p.m. Added 35 {"external_links": []}
Nov. 6, 2023, 1:31 p.m. Added 35 {"external_links": []}
Aug. 14, 2023, 1:30 p.m. Added 35 {"external_links": []}
Aug. 7, 2023, 1:31 p.m. Added 35 {"external_links": []}
July 31, 2023, 1:34 p.m. Added 35 {"external_links": []}
July 24, 2023, 1:35 p.m. Added 35 {"external_links": []}
July 17, 2023, 1:34 p.m. Added 35 {"external_links": []}
July 10, 2023, 1:26 p.m. Added 35 {"external_links": []}
July 3, 2023, 1:26 p.m. Added 35 {"external_links": []}
June 26, 2023, 1:25 p.m. Added 35 {"external_links": []}
June 19, 2023, 1:27 p.m. Added 35 {"external_links": []}
June 12, 2023, 1:29 p.m. Added 35 {"external_links": []}
June 5, 2023, 1:33 p.m. Added 35 {"external_links": []}
May 29, 2023, 1:27 p.m. Added 35 {"external_links": []}
May 22, 2023, 1:29 p.m. Added 35 {"external_links": []}
May 15, 2023, 1:31 p.m. Added 35 {"external_links": []}
May 8, 2023, 1:37 p.m. Added 35 {"external_links": []}
May 1, 2023, 1:27 p.m. Added 35 {"external_links": []}
April 24, 2023, 1:34 p.m. Added 35 {"external_links": []}
April 17, 2023, 1:28 p.m. Added 35 {"external_links": []}
April 10, 2023, 1:24 p.m. Added 35 {"external_links": []}
April 3, 2023, 1:26 p.m. Added 35 {"external_links": []}
Jan. 28, 2023, 11:08 a.m. Created 43 [{"model": "core.projectfund", "pk": 27006, "fields": {"project": 4199, "organisation": 49, "amount": 0, "start_date": "2017-09-30", "end_date": "2021-12-31", "raw_data": 42854}}]
Jan. 28, 2023, 10:52 a.m. Updated 35 {"status": ["Active", "Closed"]}
Jan. 28, 2023, 10:52 a.m. Added 35 {"external_links": []}
April 11, 2022, 3:46 a.m. Created 43 [{"model": "core.projectfund", "pk": 19114, "fields": {"project": 4199, "organisation": 49, "amount": 0, "start_date": "2017-09-30", "end_date": "2021-12-31", "raw_data": 19629}}]
April 11, 2022, 3:46 a.m. Created 41 [{"model": "core.projectorganisation", "pk": 72880, "fields": {"project": 4199, "organisation": 91, "role": "LEAD_ORG"}}]
April 11, 2022, 3:46 a.m. Created 40 [{"model": "core.projectperson", "pk": 44831, "fields": {"project": 4199, "person": 4903, "role": "STUDENT_PER"}}]
April 11, 2022, 3:46 a.m. Created 40 [{"model": "core.projectperson", "pk": 44830, "fields": {"project": 4199, "person": 4964, "role": "SUPER_PER"}}]
April 11, 2022, 1:47 a.m. Updated 35 {"title": ["", "Investigating how microcircuit abnormalities modulate brain-wide network dynamics to cause seizures across variant SCN1A mutations, using a zebrafish"], "description": ["", "\nThe aim of this investigation is to examine how SCN1A loss-of-function mutations (encoding a voltage-gated sodium channel) lead to abnormal network dynamics resulting in epileptic seizures, as reported in patients with Dravet syndrome. \n\nQuestion 1 (Q1): How does a loss-of-function sodium channel mutation lead to a paradoxical increase in neuronal excitation?\nHypothesis 1: The mutation preferentially leads to decreased excitability of inhibitory neurons causing aberrant disinhibition of excitatory neurons. \n\nQuestion 2 (Q2): How do different SCN1A mutations, causing divergent biophysical abnormalities in patients, lead to a common clinical phenotype?\nHypothesis 2: Mutations along different regions of the SCN1A gene differentially alter sodium channel gating dynamics, which downstream converge to cause network hyper-excitability. \n\nQuestion 3 (Q3): How do SCN1A mutations lead to abnormal network dynamics, as measured with light sheet fluorescence microscopy (LSFM) and electro-encephalogram (EEG)?\nHypothesis 3: SCN1A mutations result in common abnormalities in neuronal coupling across LSFM and EEG.\n\n"], "extra_text": ["", "\n\n\n\n"], "status": ["", "Active"]}
April 11, 2022, 1:47 a.m. Added 35 {"external_links": [15938]}
April 11, 2022, 1:47 a.m. Created 35 [{"model": "core.project", "pk": 4199, "fields": {"owner": null, "is_locked": false, "coped_id": "53c8237e-b27d-480a-b5c9-75240c5bf0ca", "title": "", "description": "", "extra_text": "", "status": "", "start": null, "end": null, "raw_data": 19615, "created": "2022-04-11T01:38:07.581Z", "modified": "2022-04-11T01:38:07.581Z", "external_links": []}}]