Engineering approaches to exploiting human Cardio-spheroids in Drug discovery.

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Title
Engineering approaches to exploiting human Cardio-spheroids in Drug discovery.

CoPED ID
2c1823eb-10df-41ab-aa84-ad43eaad89ce

Status
Closed

Funders

Value
No funds listed.

Start Date
Sept. 30, 2017

End Date
Sept. 29, 2021

Description

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"his is a PhD research project that integrates engineering/Physics/chemistry/biology to develop new biophysical tools to interrogate organoids in a reproducible and 'high throughput' manner. This will enable the screening of cardio relevant small compound libraries and personalised drug discovery. Cardio -spheroids (CS) are bioengineered human heart-like organoids and are emerging as powerful tools in drug discovery. These organoids are 500 'balls' of human cardiomyocytes that beat with a similar frequency to the human heart rhythm (60-70 BPM). Their electrical activity is strikingly similar to the human ECG. Drug discovery companies are producing a large number of cell lines, however, it is not clear whether these organoids will be useful in the drug discovery process, transplantation or safety testing. The size and material properties of the CSs render them unsuitable for use in conventional electrophysiological microelectrode arrays (one organoid/64 electrode array). The PhD project would involve, collaborating with Censo Technologies Ltd in standardizing the production of these organoids, developing trapping technologies that allow the flexible electrical measurement to be carried out on a large scale (custom multielectrode arrays), characterising the cell lines electrophysiologically and developing standard protocols and devices for upscaling the process.
Training will be given in cell programming, cell culture, library and compound selection, electrophysiology (multi-electrode arrays and voltage clamp), imaging and signal processing.
"

Heriot-Watt University LEAD_ORG
Epigem COLLAB_ORG
University of Edinburgh COLLAB_ORG
University Hospital of Bern COLLAB_ORG
Epigem Ltd STUDENT_PP_ORG

Euan Brown SUPER_PER
Mario Alvarez Martinez STUDENT_PER

Subjects by relevance
  1. ECG
  2. Medicinal substances

Extracted key phrases
  1. Drug discovery process
  2. Drug discovery company
  3. Personalised drug discovery
  4. Human heart rhythm
  5. Human Cardio
  6. Engineering
  7. Drug discovery
  8. Phd research project
  9. Human cardiomyocyte
  10. Human ECG
  11. Cardio relevant small compound library
  12. Phd project
  13. Like organoid
  14. New biophysical tool
  15. Organoid/64 electrode array

Related Pages

UKRI project entry

UK Project Locations
2
100 km
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