| Feb. 13, 2024, 4:20 p.m. |
Created
43
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[{"model": "core.projectfund", "pk": 67337, "fields": {"project": 15593, "organisation": 11073, "amount": 998464, "start_date": "2023-07-01", "end_date": "2025-06-30", "raw_data": 187758}}]
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| Jan. 30, 2024, 4:25 p.m. |
Created
43
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[{"model": "core.projectfund", "pk": 60158, "fields": {"project": 15593, "organisation": 11073, "amount": 998464, "start_date": "2023-07-01", "end_date": "2025-06-30", "raw_data": 168522}}]
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| Jan. 2, 2024, 4:16 p.m. |
Created
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[{"model": "core.projectfund", "pk": 53022, "fields": {"project": 15593, "organisation": 11073, "amount": 998464, "start_date": "2023-07-01", "end_date": "2025-06-30", "raw_data": 142367}}]
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| Dec. 5, 2023, 4:25 p.m. |
Created
43
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[{"model": "core.projectfund", "pk": 45768, "fields": {"project": 15593, "organisation": 11073, "amount": 998464, "start_date": "2023-06-30", "end_date": "2025-06-29", "raw_data": 123008}}]
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| Nov. 27, 2023, 2:16 p.m. |
Added
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{"external_links": []}
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| Nov. 21, 2023, 4:43 p.m. |
Created
43
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[{"model": "core.projectfund", "pk": 38499, "fields": {"project": 15593, "organisation": 11073, "amount": 998464, "start_date": "2023-06-30", "end_date": "2025-06-29", "raw_data": 80233}}]
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| Nov. 21, 2023, 4:43 p.m. |
Created
41
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[{"model": "core.projectorganisation", "pk": 116169, "fields": {"project": 15593, "organisation": 14017, "role": "PARTICIPANT_ORG"}}]
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| Nov. 21, 2023, 4:43 p.m. |
Created
41
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[{"model": "core.projectorganisation", "pk": 116168, "fields": {"project": 15593, "organisation": 10850, "role": "PARTICIPANT_ORG"}}]
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| Nov. 21, 2023, 4:43 p.m. |
Created
41
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[{"model": "core.projectorganisation", "pk": 116167, "fields": {"project": 15593, "organisation": 19766, "role": "PARTICIPANT_ORG"}}]
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| Nov. 21, 2023, 4:43 p.m. |
Created
41
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[{"model": "core.projectorganisation", "pk": 116166, "fields": {"project": 15593, "organisation": 19767, "role": "PARTICIPANT_ORG"}}]
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| Nov. 21, 2023, 4:43 p.m. |
Created
41
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[{"model": "core.projectorganisation", "pk": 116165, "fields": {"project": 15593, "organisation": 19768, "role": "PARTICIPANT_ORG"}}]
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| Nov. 21, 2023, 4:43 p.m. |
Created
41
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[{"model": "core.projectorganisation", "pk": 116164, "fields": {"project": 15593, "organisation": 19770, "role": "PARTICIPANT_ORG"}}]
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| Nov. 21, 2023, 4:43 p.m. |
Created
41
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[{"model": "core.projectorganisation", "pk": 116163, "fields": {"project": 15593, "organisation": 19769, "role": "PARTICIPANT_ORG"}}]
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| Nov. 21, 2023, 4:43 p.m. |
Created
41
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[{"model": "core.projectorganisation", "pk": 116162, "fields": {"project": 15593, "organisation": 19770, "role": "LEAD_ORG"}}]
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| Nov. 21, 2023, 4:43 p.m. |
Created
40
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[{"model": "core.projectperson", "pk": 73032, "fields": {"project": 15593, "person": 21538, "role": "PM_PER"}}]
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| Nov. 20, 2023, 2:06 p.m. |
Updated
35
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{"title": ["", "Digital_Lyo"], "description": ["", "\nThe number of biopharmaceutical injectable products continues to increase. Predictions are that 40 per cent of new molecular entities will require batch freeze-drying for stability. The freeze-drying process (lyophilization) removes water from sensitive or high-value products such as vaccines, biologics, antibiotics, to extend shelf-life without the need for refrigeration/cold-chain. Freeze-drying processes need to be sustainable and commercially viable. There is a need to accelerate batch throughput and build capacity to increase efficiency and enable timely response to unexpected demand (e.g. COVID-19). Shortening drying times reduces energy demands and emissions and improves efficiency so lowering end-product costs. This aligns with the Clean Growth Strategy.\n\nA pharmaceutical product development programme involves optimisation of formulations and processes for product viability and consistency; but product quality issues are identified at the end of a long cycle and at this stage significant costs have already been incurred. In-situ rapid analytical monitoring, giving real-time automated data, will provide feedback on and enable control of the lengthy freeze-drying process. Such insight can enable shortening of development times, reduced repeat runs and product failure/loss, lessened environmental costs and bioburden and ultimately improved product quality and consistency.\n\nFreeze-drying employs high-global warming potential (GWP) refrigerants (banned 2030) or liquid nitrogen (high energy use in manufacture) for cooling, and improving sustainability requires a fresh approach. Implementation of a continuous freeze-drying Peltier system would be capable of a step change reduction in emissions. Further, freeze-drying processes must be repurposed for the expected increase in personalised medicines and the smaller batch runs and 'just-in-time' production schedules that this involves.\n\nBy building a consortium encompassing diverse expertise in key areas we have identified multiplexed Process Analytical Technology (PAT) to provide the required rapid data for modelling the freeze-drying process. Such coupled PAT sensor technology will enable scrutiny and control of batch freeze-drying and enable future continuous freeze-drying processes. Anticipated CO2 savings are in the order of 700 tonnes per newly developed product, achieved by reduced development cycles and increased production efficiencies in the order of 1 per cent. This is equivalent to savings of CO2 emissions of 300 tonnes per year per freeze-dryer.\n\nThis innovative multiplexed approach offers insight potential for in-depth analysis of factors impacting batch manufacturing freeze-drying efficiency. It further affords the opportunity to enhance process understanding of the freezing and drying stages to de-risk the deployment of new continuous manufacturing techniques, and ultimately maximise their efficiency and sustainability.\n\n"], "extra_text": ["", "\n\n\n\n"], "status": ["", "Active"]}
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| Nov. 20, 2023, 2:06 p.m. |
Added
35
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{"external_links": [61271]}
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| Nov. 20, 2023, 2:06 p.m. |
Created
35
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[{"model": "core.project", "pk": 15593, "fields": {"owner": null, "is_locked": false, "coped_id": "98d8ad6f-f52b-4a53-af2c-a26c5e131d70", "title": "", "description": "", "extra_text": "", "status": "", "start": null, "end": null, "raw_data": 80216, "created": "2023-11-20T13:58:57.824Z", "modified": "2023-11-20T13:58:57.824Z", "external_links": []}}]
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