| Feb. 13, 2024, 4:20 p.m. |
Created
43
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[{"model": "core.projectfund", "pk": 66488, "fields": {"project": 14737, "organisation": 11086, "amount": 1718015, "start_date": "2022-09-01", "end_date": "2027-08-31", "raw_data": 186572}}]
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| Jan. 30, 2024, 4:25 p.m. |
Created
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[{"model": "core.projectfund", "pk": 59314, "fields": {"project": 14737, "organisation": 11086, "amount": 1718015, "start_date": "2022-09-01", "end_date": "2027-08-31", "raw_data": 166924}}]
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| Jan. 2, 2024, 4:16 p.m. |
Created
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[{"model": "core.projectfund", "pk": 52174, "fields": {"project": 14737, "organisation": 11086, "amount": 1718015, "start_date": "2022-09-01", "end_date": "2027-08-31", "raw_data": 141250}}]
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| Dec. 5, 2023, 4:24 p.m. |
Created
43
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[{"model": "core.projectfund", "pk": 44919, "fields": {"project": 14737, "organisation": 11086, "amount": 1718015, "start_date": "2022-08-31", "end_date": "2027-08-30", "raw_data": 117835}}]
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| Nov. 27, 2023, 2:15 p.m. |
Added
35
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{"external_links": []}
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| Nov. 21, 2023, 4:42 p.m. |
Created
43
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[{"model": "core.projectfund", "pk": 37643, "fields": {"project": 14737, "organisation": 11086, "amount": 1718015, "start_date": "2022-08-31", "end_date": "2027-08-30", "raw_data": 76030}}]
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| Nov. 21, 2023, 4:42 p.m. |
Created
41
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[{"model": "core.projectorganisation", "pk": 112554, "fields": {"project": 14737, "organisation": 11661, "role": "LEAD_ORG"}}]
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| Nov. 21, 2023, 4:42 p.m. |
Created
40
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[{"model": "core.projectperson", "pk": 70712, "fields": {"project": 14737, "person": 20274, "role": "PI_PER"}}]
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| Nov. 20, 2023, 2:06 p.m. |
Updated
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{"title": ["", "Enzyme e-map - Modernising Electrochemical Enzymology To Map Electron Transfer"], "description": ["", "\nIn Nature the production of hydrogen and methane fuel molecules from readily available starting materials such as water and carbon\ndioxide is achieved selectively, efficiently and rapidly by electrocatalytic redox-metalloenzymes containing non-precious transition\nmetal active sites. The outstanding recent scientific advances made in molecular biology have made the development of biofuel\ntechnologies based on these enzymes a reality, but such applications require a complementary toolkit of physical chemistry methods\nthat can dissect how DNA sequence and protein structure relates to function. Classic bio-electrochemistry methods developed in the\n1980s have been a powerful way to probe the active site reactivity of such enzymes, but they have been unable to map the electron\ntransfer processes which underpin the catalysis. Therefore, we have been limited to a narrowly active-site focussed view of enzyme\nmechanism. This project will transform the state of the art in bio-electrochemistry to deliver a powerful new technique that can "see"\nthe electron-transfer processes of the highly evolved and essential electron-transfer reaction centres in redox-enzymes, and deconvolute\ntheir role in electrocatalysis. This will be achieved by deploying advanced computational methods to integrate intelligent\nexperimental design into electrochemistry to develop a methodology that lets us separate and accurately model the electron transfer\nprocesses of an enzyme bound to substrate, and chemical biology methods to develop linker molecules for light-activated electrografting\nof proteins and enzymes onto electrodes. We will showcase the power of this new electrochemical enzymology toolkit by\nconducting previously impossible hypothesis-led investigations and enzyme-discovery projects into i) cellulose-degrading LPMOs\nthat play a crucial role in biorefinery enzyme cocktails and ii) hydrogenases, Ni+Fe or Fe-only metalloenzymes that are as rapid and\nefficient at hydrogen-catalysis as platinum.\n\n"], "extra_text": ["", "\n\n\n\n"], "status": ["", "Active"]}
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| Nov. 20, 2023, 2:06 p.m. |
Added
35
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{"external_links": [58252]}
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| Nov. 20, 2023, 2:06 p.m. |
Created
35
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[{"model": "core.project", "pk": 14737, "fields": {"owner": null, "is_locked": false, "coped_id": "251d2b19-b328-4910-8f9b-9e1289e21dfa", "title": "", "description": "", "extra_text": "", "status": "", "start": null, "end": null, "raw_data": 76013, "created": "2023-11-20T13:55:29.706Z", "modified": "2023-11-20T13:55:29.706Z", "external_links": []}}]
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