Feasibility study of a novel calcium phosphate-based composition for orthopaedic device applications

Find Similar History 12 Claim Ownership Request Data Change Add Favourite

Title
Feasibility study of a novel calcium phosphate-based composition for orthopaedic device applications

CoPED ID
ede02f47-bc01-4550-be68-03d19c90f79d

Status
Closed


Value
£600,215

Start Date
Jan. 1, 2020

End Date
Dec. 31, 2020

Description

More Like This


SIRAKOSS developed and manufacture a novel calcium phosphate-based bone graft substitute for use in spinal and trauma surgery and the first product was recently CE-marked. This material has shown excellent performance in pre-clinical models of these surgeries but the nature of this material has a disadvantage in that it cannot be processed using high temperatures (\>1000°C) that traditional calcium phosphate materials can be. This means it cannot be sintered to form a macroporous ceramic, so can't utilise 3D printing approaches to manufacture complex/custom implant designs, and it cannot be coated onto medical devices using industry standard approaches. We have identified a process to modify our existing technology to produce a new composition that initial studies have shown is thermally stable at the high temperatures required to manufacture such ceramics and coatings. This project aims to characterise fully this new composition, test its ability to be formed into a macroporous ceramic, and screen these samples in a pre-clinical study to evaluate the bone healing response. This proof of concept would allow SIRAKOSS to be able to develop new products in the future that utilise this new formulation, which could include customised implants utilised 3D printing and bioactive coatings in spinal cages and other orthopaedic medical devices.

SIRAKOSS LIMITED LEAD_ORG
SIRAKOSS LIMITED PARTICIPANT_ORG

Iain Gibson PM_PER

Subjects by relevance
  1. Implants
  2. Bone
  3. Ceramics industry
  4. Product development
  5. Manufacturing
  6. 3D printing
  7. Ceramic materials
  8. Biomaterials

Extracted key phrases
  1. Novel calcium phosphate
  2. Traditional calcium phosphate material
  3. Feasibility study
  4. Clinical study
  5. New composition
  6. Orthopaedic device application
  7. Initial study
  8. Orthopaedic medical device
  9. Bone graft substitute
  10. New product
  11. Bone healing response
  12. 3d printing approach
  13. Macroporous ceramic
  14. New formulation
  15. High temperature

Related Pages

UKRI project entry

UK Project Locations